For patients suffering from protein-catabolic conditions such as HIV disease and tuberculosis in poor countries, it is very important to improve the supply of cheap high-quality protein either from local agriculture or through improvement of the utilization of cheap fish resources for human consumption (which may be possible especially when using pelagic fish living in regions of oceanic upwelling, e.g. off the coasts of Namibia and Angola). Making Se-enriched animal products such as goat milk (from high-yielding dairy goats, e.g. by using salt licking stones containing Se-met) would appear a good strategy for improving the nutrition status of HIV patients in rural areas in Sub-Saharan Africa. It might help to correct several different nutrient deficiency conditions, being especially important in this context at the same time as it can be done cheaply in an ecologically acceptable way, especially when combined with agroforestry (and in hilly terrain also terrace construction) as methods of improving soil fertility.
- Haug, 2007 (How to use the world's scarce selenium resources efficiently to increase the selenium concentration in food.)
Malondialdehyde levels were significantly reduced in the intervention group (P = 0.01), while there was minimal reduction in the control group. The mean plasma level of total antioxidants was increased significantly (P = 0.001) in both the intervention and the control groups.
A 2-month intervention with vitamin E and selenium supplementation reduces oxidative stress and enhances total antioxidant status in patients with pulmonary TB treated with standard chemotherapy."
Malondialdehyde: a marker for oxidative stress
At baseline, the tuberculosis group had lower serum selenium levels than did the control group. The conversion of bacteriological tests was associated with the CRP/albumin ratio and serum selenium levels 60 days after treatment initiation.
Higher serum selenium levels after 60 days of treatment were associated with the conversion of bacteriological tests in pulmonary tuberculosis patients.