14 September 2018 ·
Glutamate triggers long-distance, calcium-based plant defense signaling
A plant injured on one leaf by a nibbling insect can alert its other leaves to begin anticipatory defense responses. Working in the model plant Arabidopsis , Toyota et al. show that this systemic signal begins with the release of glutamate, which is perceived by glutamate receptor–like ion channel...
Fred Baker I took a look at this. My wife is a farmer, we have had a fire in the orchard recently, and I'm genuinely interested in the topic. However, going to read it, I found endless pages of licenses and discussions of licenses. Do you have something of substance to report, such as a link at which I can actually go read the paper?
Bill Manning these folks are PPV. You could ask one of the authors directly for a copy... < email@example.com >
Richard Sexton stick sci-hub dot tw in front of the url and you can read anything now.
I've written about thie phenomenon before in an aquarium magazine once or twice as "melt" is a very minor problem with aquatic plants but in one particular exoric genis they're very prone to it.
There are a number of pathways that do this, from powdery mildew to programmed cell death ti various chemicals that send messages to other members of the species and all plants in general, plus there's mechanical issues, any leaf a melting Cryptocoryne leafs fall on will die period, and this is chemical as it happens when filtered through a sub micron ceramic filter.
So what happened after the fire when half burned? Must have been the year for it, we had a house fire too. Some prick of a professional arsonist.
Christopher Wilson shared a link.
18 September 2018
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How studying chicken butts cracked the inner workings of our immune system
Children were dying, and pediatrician Max Cooper couldn’t understand why. They had plenty of plasma cells, which he knew produced antibodies, but his patients who were suffering from a rare hereditary disease called Wiskott-Aldrich syndrome were still failing to fight off simple herpes infections....
Richard Sexton "fight off simple herpes infections"
It's an enveloped virus unable to form the initial chemical bond with the cellular membrane of the host cell when the disulphide bond it needs to form is inhibited by th correct level of serum selenium (Lipinski 2015).
This wasn't discovered in the last century so they'd need to find a more current source of understanding of virology and medial chemistry..
18 September 2018 ·
Physiochemical basis of human degenerative disease
The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, ...
18 September 2018 ·
The availability of structures and linked bioactivity data in databases is powerfully enabling for drug discovery and chemical biology. However, we now review some confounding issues with the divergent expansions of public and commercial sources of chemical structures. These are associated with not only expanding patent extraction but also increasingly large vendor collections amassed via different selection criteria between SciFinder from Chemical Abstracts Service (CAS) and major public sources such as PubChem, ChemSpider, UniChem, and others. These increasingly massive collections may include both real and virtual compounds, as well as so-called prophetic compounds from patents. We address a range of issues raised by the challenges faced resolving the NIH probe compounds. In addition we highlight the confounding of prior-art searching by virtual compounds that could impact the composition of matter patentability of a new medicinal chemistry lead. Finally, we propose some potential solutions.
Chemistry and Bioactivity Data: From Famine to Feast to Overload
It is hard to imagine now that in the early 2000s there was a dearth of chemistry and bioactivity data that were publicly accessible. Yet in the decade since the appearance of the large publically accessible PubChem1 and ChEBI databases2 we are arguably approaching an era of drug-discovery-related data overload as data ....
Parallel Worlds of Public and Commercial Bioactive Chemistry Data