Last time I had my cholesterol checked it was 320 and my doctor prescribed Welchol, which was 6 huge pills to take all at once daily. It brought my cholesterol down to 230 which pleased my doc. I hated taking the med, so I stopped taking it. Then I learned about Niacin. After about a year of 1000mg Inositol Hexanicotinate 2x/ day (not a fan of the flush), I had blood work done. My cholesterol is now 232! Niacin is as effective as medication!